Functional Genetic Testing available at Wellness Alternatives, refers to how an individual’s genes are expressed within a particular environment. Each person has a unique genetic makeup, which includes a combination of single nucleotide polymorphisms (SNPs) specific to the individual. A SNP is a variation of a single base pair and is the most common type of genetic mutation. Some SNPs can result in an alteration in the structure and function of certain enzymes, thereby affecting an individual’s health.
As a result of this genetic individuality, two people in the same environment can have genes with very different expression. Conversely, because genetic expression is also influenced by the environment, the same person can have genes expressed differently in different environments.
SNPs can result in reduced function of biochemical pathways, which can lead to:
- Neurodegenerative disorders
- Cardiovascular issues
Available Functional Genetic Profiles
Contact Dr. Dave at Wellness Alternatives to order your Functional Genetic Profile.
The Oxidative Stress Genetic profile assess the genes which protect against oxidative stress and are responsible for destroying toxic free radicals and reactive oxygen species (ROS) in the body. Genes: SOD1, SOD2, SOD3, GPx1, CAT
Vitamin D deficiency is common among older adults, but often begins at an earlier age. Low levels of vitamin D have been associated with early onset of osteoporosis and are involved in oxidative stress and premature aging.
There is now biologic evidence that vitamin D may protect against autoimmune diseases and certain cancers. The active form of vitamin D produces and maintains self immunologic tolerance, some studies show that 1,25(OH)2D inhibits induction of disease in autoimmune conditions, thyroiditis, inflammatory bowel disease (IBD), systemic lupus erythematosus, and collagen-induced arthritis and Lyme arthritis. Genes: VDR, CYP27B1, GC
Neurotransmitter Synthesis/Folate Methylation
This profile identifies gene variants affecting the synthesis and inactivation of specific neurotransmitters. Variant in methylene-tetrahyrofolate reductase (MTHFR) may affect synthesis of serotonin and catecholamine neurotransmitters as well as homocysteine from the blood efficiently. COMT variants may reduce inactivation of catecholamine neurotransmitters. Genes: COMT, MTHFR
Celiac & Gluten Sensitivity
Celiac and Gluten Sensitivity are accompanied by genetic variants of the HLA-DQA1 and HLA-DQB1 genes, which belong to the HLA complex. The HLA complex helps the immune system to distinguish between the self proteins and those made by foreign invaders such as viruses and bacteria. Genes: HLA-DQ2.5, HLA-DQ8
The metal detoxification profile assesses an individual’s susceptability to metal toxicity, carcinogens and other toxins including various therapeutic drugs. Gene: GSTM1
Multiple Drug Resistance
The multidrug resistance 1(MDR1/ABCB1) gene encodes the transport of protein P-glycoprotein (a phase III xenobiotic transporter). It is present in the intestinal mucosal lining and restricts absorption of certain carcinogens, like polycyclic aromatic hydrocarbons. P-glycoprotein transports various substrates involved in inflammation such as cytokine and chemokines, and may thereby affect the risk of malignancy. Genes: MDR1
Call Today for more information on Functional Genetic Testing. 530-615-4083