Three Stages of a Woman’s’ Life Requires Three Different Estrogens

9448857_sEstrogen is important for a healthy uterus. Collectively estrone, estradiol and estriol are referred to as estrogen. The three different types of ‘Estrogen‘ have differing roles during the reproductive years, pregnancy and menopause. Hormones maintain the lining of the uterus by causing the shedding, growth and maturation for the possibility of pregnancy, during pregnancy and finally during menopause. Each taking a predominant role during the different times. 

  • Estrone – Maintains healthy thin uterine lining during menopause
  • Estradiol – Maintains healthy uterine lining for possible pregnancy during reproductive years
  • Estriol – Maintains thick uterine lining providing blood to the placenta during pregnancy

Menstruation is part of the menstrual cycle, which prepares a woman’s body for pregnancy each month. The cycle is counted from the first day of one period to the first day of the next period. Hormones rise and fall during the month to make the menstrual cycle happen.

Remodeling of the uterine arteries is a key event in early pregnancy that begins after implantation. The placenta is a unique vascular organ that receives blood supplies from both the maternal and the fetal systems and thus has two separate circulatory systems for blood: (1) the maternal-placental (uteroplacental) blood circulation, and (2) the fetal-placental (fetoplacental) blood circulation.

Remodeling occurs again during menopause as the uterine lining shrinks. After menopause, the uterus becomes smaller without monthly production of female hormones, although the degree of shrinkage is less in the cervix than in the rest of the uterus.

Three Types of Estrogen


There are three estrogens that control the phases of a women’s life are:

Estrone (E1): is the least abundant of the three hormones (estradiol, estriol, and estrone).  Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone is the only one of the three estrogens, which is present in any quantity in menopausal women.

An abnormal level of Estrone can manifest in both your behavior and physical attributes. As ovarian reserve diminished estrone becomes the dominant estrogen.

What are the Signs & Symptoms of Estrone Hormonal Imbalance?

Before you read the signs and symptoms of Estrone hormonal imbalance, it’s crucial to understand that these signs and symptoms may differ from one woman to another. Typically, symptoms of Estrogen dominance are dependent on the lifestyle and family history of the individual amongst other reasons. However, that being said, some of the most common symptoms of Estrone hormonal imbalance include:

  • Allergies
  • Asthma
  • Irregular periods
  • Swollen/Fibrocystic Breasts
  • Irritability
  • Fatigue
  • Lack of stamina
  • PMS
  • Infertility
  • PCOS (polycystic ovarian syndrome)
  • Fibroids
  • Mood Swings
  • Magnesium deficiency
  • Thyroid dysfunction

Estradiol (E2): is the most active of the estrogens, the female sex hormones, and is responsible for the development of female sex organs and characteristics.  In adults estradiol slows the breakdown of bone. Estradiol levels fall dramatically in menopause. Estradiol is often prescribed after menopause to maintain skeletal health and may reduce the risk of cardiovascular disease. Estradiol is thought to help regenerate and preserve nerve cells in the brain. This may explain the delayed onset and slowed progression of Alzheimer’s seen in women on estrogen therapy.

The principal estrogen secreted by the ovaries is estradiol, which is 12 times as potent as estrone, and 80 times as potent as estriol. For this reason estradiol is considered to be the major estrogen, although the estrogenic affects of estrone are far from negligible.

Estriol (E3): is the weakest of the naturally occurring estrogens that occurs and is mainly produced by the placenta during pregnancy. Small amounts are made in other organs (eg. Ovaries and adrenal glands). Estriol is produced in large quantities during pregnancy and can be used as an indicator of fetal well-being and to predict pre-term labor. Estriol is thought to have anti-breast cancer effects.

High hormone levels

Saliva Hormone Test from 53 year old woman with the Estiol (pregnancy hormone) greater than 100 pg/ml. All from Bio-Identical Progesterone.

2. THE PROGESTINS C21 STEROIDS are your progestins with the most important progestin called progesterone.  However there are small amounts of other hormones such as pregnenolone (the key precursor to all steroid hormones) and 17-alpha-hydroxyprogesterone, which are also secreted with progesterone and have the same effects.  Progesterone is secreted in large amounts during the latter stages of the ovarian cycle by the corpus luteum.  The placenta during pregnancy also secretes progesterone especially after the fourth month of gestation.  The adrenal cortex also plays a role in progesterone production. Progesterone the principle secretory hormone of the corpus luteum does the following:

  • Required for implantation of the fertilized egg
  • Maintains pregnancy
  • Inhibits uterine contractions
  • Promotes breast gland development
  • Increases body temperture
  • Induces decidualization of the endometrium

Progesterone: is a steroid hormone responsible for the changes in the uterine endometrium during the second half of the menstrual cycle in preparation for implantation. It is used to treat menstrual disorders, among other problems. Progesterone has been described as the “feel-good” hormone and low levels can cause irritability and anxiousness. Progesterone reduces the expression of estrogen receptors and can become anti-estrogenic when in excess. Progesterone is produced primarily by the corpus luteum in women and is present only in low amounts in men.

3. STEROIDS produced by the ovaries are dehydroepiandosterones (DHEA’s) with androstenedione being the most important since it can be converted into testosterone or estrogen in the ovary’s or extraovarian tissue and testosterone produced by the theca cells and ovarian stroma..  Synthesis of estrogens and progestins are mainly derived from cholesterol in the blood and to a slight extent from acetyl co-enzyme A.  Several sources of cholesterol exist such as:

  • Lipoprotein cholesterol from the blood
  • Cholesterol synthesized by the ovary itself
  • Intracellular stores of LDL’s in the ovary

Steroidogenesis (Hormone producing) Enzymes

Steroidogenesis is the biological process by which steroid hormones are generated from the cholesterol building block and transformed into other steroid hormones by enzymes.[i]

Cholesterol + Enzyme (Cholesterol monooxygenase) = Pregnenolone

Cholesterol is essential for sex hormone production and a healthy stress response. Diets that cut out cholesterol, put the body at a disadvantage when trying to conceive. Other metabolic factors such as malabsorption, insulin resistance, and thyroid conditions can lead to top dow disruption if homeostatic parameters are not met.

Etiocholanolone 2

Arrows point to upstream hormones. Each arrow represents a enzyme responsible for converting the hormone into the next hormone. Etiocholanolone is an inflammation producing hormone.

Bad Enzymes equal Bad Hormones

The body is a chemistry laboratory. There are many things that can make this process go awry. The biological terrain impacts every biochemical process in the body including… ENZYMES. There are hundreds if not thousands of enzyme processes, which take place in the body. Many are so specific that they are like complex square pegs that need to “fit” into specific square holes in order to carry out their duty. If biological terrain in the blood, gut, or in any other part of the body is off balance even a little, some important pegs are not “fitting” their respective slots.

Hormone + Enzyme —-> Upstream hormone

When the Gene is functioning properly, it makes 100% of the enzyme, which makes 100% of the Upstream hormone. Now, if the gene is damaged by inflammation or the biological terrain changes the enzymes or hormones shape, it can’t make as much of the Upstream hormone as it normally would.

Hormone + Damaged Enzyme —-> 65% of Upstream hormone

This makes me think of my under graduate chemistry lab. We did a lab experiment that was done with a specific set of ingredients in a specific sequence which in theory should have made a specific amount of stuff. Which was compared to the theoretical amount if everything was perfectly done. In reality, it was more like potions class at Hogwarts. The same thing happens in our body with changes in a Ghetto Gut, the biological terrain and the NEI supersystem.

Damaged Hormone + Damaged Enzyme —-> 25% of Upstream hormone

The first step to living a healthier life is realizing that you’re not in charge. The hormones, enzymes, and bacteria are in full control. The bad news is that living healthier may not be as easy as you’ve been told. The good news is that knowing who’s in charge equips you with the information you need to start taking steps in the right direction. Hormones, enzymes, and bacteria aren’t to be trifled with, you send them the wrong signals, and eventually it will catch up with you. Keep in mind that everything you put into your body can have an effect the biological terrain. Restoring the biological terrain and the NEI Supersystem is the best way to move you back into health. Call today.

One thought on “Three Stages of a Woman’s’ Life Requires Three Different Estrogens

  1. Pingback: Anemia of Chronic Inflammation is the Evil Twin of Iron Anemia. | Living Wellness

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