Systemic Toxicity from Bowel Gasses

5594641_sGasotransmitters in the Gastrointestinal Tract

The 1990s initiated a new form of “neurotransmitters” with the discovery that a gas, nitric oxide (NO), could be released specifically from nerves and act to transmit the “neural signal” secondary to nerve stimulation. But, unlike the classic paradigm of a neurotransmitter being released from nerves, NO is also formed in the gastrointestinal tract and by microbes to stimulate the neural signals.

The recognition of carbon monoxide (CO) soon followed as a second gaseous neurotransmitter acting similarly to NO. With the recent acknowledgement of hydrogen sulfide (H2S) as the third gaseous neurotransmitter, the term “gasotransmitter” was introduced to characterize gases which act as neurotransmitters. All three are produced under physiologic conditions, and released in the Second Brain or enteric nervous system.

Due to their gaseous nature, NO, CO, and H2S are not stored within the nerve cell before they are released, but rather they are formed in the gut and by microbes, which distinguishes these gasotransmitters from classic neurotransmitters such as acetylcholine, norepinephrine, and even the peptide neurotransmitters.

Gasotransmitters are rapidly scavenged or enzymatically degraded after their release to terminate their signaling activity, with biologic half-lives on the order of seconds. An additional property shared by the three gasotransmitters is their potential systemic toxicity at high concentrations from microbial production.

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Fill out the 2100 GIFX – Stool & Bowel Assessment Form

Send in the Thyroid Health Assessment Form or 2100 GIFX – Stool & Bowel Assessment Form to schedule a free 15 minute consultation.

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Nitric Oxide is produced under physiologic conditions, primarily in the form of nitric oxide synthase (nNOS) and released from inhibitory neurons of the Second Brain or enteric nervous system. Endothelial NOS (eNOS), which is also expressed constitutively in endothelial cells of the gut lining, is involved in the control of blood supply in the gut, while the inducible isoform of NOS (iNOS) is expressed mainly in inflammatory cells like macrophages, and its expression can be induced by cytokines; indeed the production of NO by iNOS can release concentrations of NO two to three log-fold greater than nNOS or eNOS and lead to markedly different physiologic and inflammatory effects.

Impaired NOS gasotransmitter responses of the muscle appears to play a crucial role in several disorders of GI dysmotility, such as difficulty swallowing food, impaired digestion, delayed stomach emptying, narrowing of the opening of the stomach, Hirschsprung′s disease, and also Chagas′ disease. In contrast, the release of NO produced by iNOS in inflammatory cells inhibits contractile activity of the intestine.

Carbon monoxide (CO) has been identified as the second gasotransmitter in the GI tract, although the role and importance of CO is less well-studied than NO. While carbon monoxide (CO) is toxic in high doses, our body has the ability to produce this gas since it is necessary for many essential physiological processes. CO is synthesized from microbial fermentation of food in the gastrointestinal tract or especially with high amounts of iron in the gut or blood stream. CO can kill certain types of microbes and is produced the same as NO and H2S by microbes to protect their turf in the gastrointestinal tract. CO is synthesized from microbial fermentation of food in the gastrointestinal tract. CO is synthesized from the breakdown of heme by heme oxygenases (HO). Much of the generated CO is scavenged by hemoglobin in red blood cells as COHb and transported to the lungs where it is exhaled. Similar to NO, three isoforms of HO have been described. The inducible isoform HO-1, which can be upregulated in response to oxidative stress or inflammation. Similar to NO, the release of CO also causes smooth muscle relaxation in the gut.

The most recent candidate to join the family of gasotransmitters is Hydrogen Sulfide (H2S). H2S is best known probably from its characteristic smell of rotten eggs and causes the discoloration of skin while wearing costume jewelry. As with NO and CO, H2S is involved in a multitude of physiologic functions, including immune and inflammatory processes, perception and pain mediation, as well as control of gastric mucosal integrity, vascular tone. In addition to the effect of H2S as a gasotransmitter affecting GI contractile activity, there is growing evidence that H2S plays an important role as a pro-inflammatory mediator in abdominal infection, toxins in the blood, and pancreatitis.

The toxic gas H2S is produced by enzymes and microbes in the body. At moderate concentrations, H2S elicits physiological effects similar to hibernation. Many consider this constant fatigue to be associated with the thyroid. It also brings to question those diagnosed with narcolepsy. The phenomenon is reversible by clearing the H2S out of the system.

In addition, hypothermia induced by hydrogen sulfide is another consequence. Again, many consider this constant fatigue to be associated with the thyroid. Sulphate-reducing bacteria are so successful in producing hypothermia and inducing hibernation, they were studied for a short time by NASA to put astronauts into hibernation during trips to Mars. Unfortunately, the bad affects outweighed the desired effects.

Other Signs and Symptoms of Hydrogen Sulphide

  • Rotten egg odor of hydrogen sulfide
  • Discoloration of skin by copper jewelry or coins
  • Foul smelling stool

Exposure to low-level concentrations can result in:

  • Eye irritation
  • A sore throat and cough
  • Nausea
  • Shortness of breath
  • Fluid in the lungs.

Long-term low-level exposure may result in:

  • Fatigue
  • Loss of appetite
  • Headaches
  • Irritability
  • Poor memory
  • Dizziness.

Symptoms that may arise, in typical order of occurrence, include:

  • Digestive or bowel complaints such as diarrhea, constipation, gas pains, bloating, or belching.
  • Foul smelling stool/gas
  • Nausea, vomiting, loss of appetite and weight loss.
  • Overall weakness.
  • Enlarged liver and gallbladder.
  • Itching.
  • Clay or light colored stools.
  • Blood clots in the legs.
  • Hair loss

Avoid Sulphate, Sulphite containing foods including but not limited to:

  • Glucosamine Sulphate, Chondroitin Sulphate, MSM and other sulphate containing supplements.

Fill out the Thyroid Health Assessment Form

Fill out the 2100 GIFX – Stool & Bowel Assessment Form

Send in the Thyroid Health Assessment Form or 2100 GIFX – Stool & Bowel Assessment Form to schedule a free 15 minute consultation.

Call today! 530-615-4083

 

4 thoughts on “Systemic Toxicity from Bowel Gasses

  1. Wow ! super article. If we clear the Sulfuration pathway (CBS pathway), I am assuming that this would help with the sign and symptoms of H2S? Would that also be more prevalent for people with CBS gene being homo or heterozygous?

    • Anne, That gene thing is a big bugaboo. Genes are sexy and the latest effort to find out why people feel the way they do. The gas in the articles is formed by microbes in the gastrointestinal tract and not at the cellular level in cells far away from the gut. Unfortunately, very few are looking at microbes because until the last five years most have been relying on aerobic culture testing of anaerobic microbes in the gut. This would be like studying fish in the ocean by putting them in a kiddie pool on a parking lot during the summer and coming back eight days later to identify the fish in the sea. They are all dead except for the Candida fish.
      Sulphate is a natural preservative in processed foods and even on fruits and vegetables. Sulphate is as hard to avoid as gluten because so many products use it. Even if a person is trying to eat healthy, they are still exposed through produce. In a Ghetto Gut, which most people that feel poorly have. Microbes will change their diet to sulphates producing the Hydrogen sulphide (H2S). H2S is very toxic to other microbes and cells in the body. Sulphate-reducing bacteria (SRBs) poison other microbes becoming the predominant species. This gas produced by SRBs is very damaging and/or deadly to cell surfaces. This over production of gas then overwhelms the elimination pathways by damaging the cells supporting clearance. The best way to determine if one has SRBs is the Metametrix 2100 Gastrointestinal Function Profile.

  2. Pingback: What is the NEI Supersystem? | Living Wellness

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